Currents for the Pharmacy Training and you may LearningAsma El-Magboub, Ian S
Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a kuumimmat naiset Saksa facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physical objectives and you will pharmacology from curcumin
Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin is the big part of brand new red-colored dye of turmeric, a keen Indian spice that is taken from the fresh new rhizome of one’s tropical plant Curcuma longa, and that belongs to the Zingiberaceae friends. Within this chapter, i discuss the pharmacological activities from curcumin and you will explore this new molecular basics for those issues. I upcoming feedback new proven and prospective systematic spends of curcumin. Curcumin is famous usually just like the a curative broker, however, the apparatus out of step are detailed. The fresh new pharmacological effects of curcumin seem to be caused by a great synergism of companies out-of poor biochemical relations with several biological purpose inside interconnected signaling routes. Such purpose include enzymes such as for example cyclooxygenase, lipoxygenase and necessary protein kinases, and you can transcription affairs instance NF-?B, STAT and you will Nrf2. Modulation ones molecules has an effect on downstream affectors that produce the latest antiinflammatory, antioxidant, chemopreventive, anticancer, and you will antimicrobial activities of curcumin. These types of outcomes were checked out inside the scientific samples from curcumin to possess problems and inflammatory disease, disease, Alzheimer condition, aerobic sickness, and you may diabetes. This new samples used changeable dosage out-of curcuminwith additional frequencies and years, toward standard achievement one to higher dosages out of curcumin from the level of grams must see therapeutic consequences. Find out more
Curcumin: Synthesis, Emerging Part inside the Pain Management and you may Health Effects
Book Section Samples of plant-derived pharmaceuticals which have get to be the desire out-of continuous and you can exponential look and you will innovation focus keeps, up until now, come somewhat scarce. After a long period, the past 2 decades have been characterized by good 100-bend increase in exactly how many scientific content authored per year you to try regarding benefits towards the the means to access curcumin in the biomedicine. Read more
Structure, synthesis and physical factors regarding curcumin prodrugs
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin has some potential pharmacological effects and may also features healing software in a lot of condition says, given that chatted about in more detail in the last part. However, the potential health-related efficacy off curcumin is bound by the the physicochemical functions of terrible liquids solubility and you may imbalance, and that end in lower bioavailability. Prodrugs from curcumin promote a means to upgrade of your biopharmaceutical and you can pharmacokinetic functions, and may succeed exploitation of your pharmacological negative effects of curcumin. Inside chapter, we basic comment brand new physicochemical and pharmacokinetics from curcumin. We after that establish the style of curcumin prodrugs which have improved h2o solubility and you may increased chemical substances balance which may be converted returning to totally free curcumin upon bioactivation inside the vivo. I focus on latest success of this type, which have a concentrate on the design, synthesis and you may evaluation from prodrugs considering promoieties as well as proteins, essential fatty acids, nucleic acids, dicarboxylic acids, and you may polymeric content such as for example hyaluronic acidic and polyethylene glycol. So it chapter comes with the basis for optimisation of physicochemical and biopharmaceutical characteristics in addition to physical things off curcumin prodrugs, for the goal using of these curcumin derivatives in the medical programs. Find out more